The position is offered for a period of three years and employment is governed by the Protocol on PhD Research Fellows signed by the Danish Ministry of Finance and AC (the Danish Confederation of Professional Associations) on 1 October 2008, enclosure 5. The salary depends on seniority, as agreed between the Ministry of Finance and AC within the range of 23.000-30.000 DKK/month (approximately 3.100-4.000 Euro/month) for a PhD position plus a pension supplement of 17 %. The PhD candidate will be expected, over the period of the stipend, to acquire experience in teaching or other types of presentations. The tentative start date is 1 March 2011.
Background: The research at the Department of Proteomics is headed by Prof. Dr. Matthias Mann and consists of three independent groups (group leaders: Dr. Chunaram Choudhary, Dr. Michael L. Nielsen and Prof. Jesper V. Olsen). You will be part of a young and dynamic team consisting of about 20 international researchers from EU, Asia and USA. The working language at the Center is English. We use cutting-edge MS technologies for unbiased identification and quantification of posttranslational modifications as well as for global proteome quantitation (Choudhary and Mann, Nat Rev Mol Cell Biol. 2010 Jun;11(6):427-39.; Choudhary et al., Mol Cell. 2009 Oct 23;36(2):326-39.; Choudhary et al., Science. 2009 Aug 14;325(5942):834-40.).
The department aims at continuously improving and applying the proteomic platform to investigate diverse biological processes. Using these approaches we will study cellular outcomes at ‘systems-level’ in response to different perturbations (such as growth factor stimulation, gene knockdown etc.). Furthermore, we use protein and peptide pull-down approaches to identify specific interaction partners. In addition to a state-of-the-art mass spectrometry infrastructure, the department is also well equipped for performing follow-up studies using molecular biology, cell biology and biochemistry techniques.
The Department of Proteomics, Novo Nordisk Foundation Center for Protein Research (CPR) offers one PhD fellowship for appointment by March 2011 or soon thereafter. It is a prerequisite that the PhD candidate is enrolled as PhD student at the Faculty of Health Sciences, University of Copenhagen, according to the rules stipulated in “Bekendtgørelse Nr. 18 af 14. januar 2008 om ph.d.-graden”. The candidate should be able to conduct independent and creative research, demonstrate scientific productivity, and show good inter-personal and communication skills.
Recently, we have improved mass spectrometry-based proteomics methods for unbiased analysis of in vivo acetylation sites (Choudhary et al., Science Aug 14;325 (5942):834-40.). The applicant will use this cutting-edge technology to analyse protein lysine acetylation on a global level, and to identify regulatory acetylation sites under different cellular perturbations. In addition, our group is interested in investigating cross-talk between regulatory PTMs such as acetylation and ubiquitylation. The candidate is expected to perform biological follow-up experiments on novel and interesting findings derived from these proteome-wide PTM screens.
The PhD student will work in the Department of Proteomics together with Group Leader, Dr. Chunaram Choudhary.
Qualifications:
The candidate is required to have a M.Sc. or equivalent degree in natural or medical science.
Excellent academic track record.
Prior experience in biochemistry, cell culture and/or protein chemistry techniques is desirable.
Knowledge in one or more of the following area(s) would be considered an advantage: genetics and biology, cell signaling, high-throughput protein-protein interactions, or chromatin biology.
Prior experience in high resolution mass spectrometry is not essential.
Good communication skills, both oral and written.
An analytical aptitude for devising innovative scientific or technical solutions.
Demonstrate enthusiasm, motivation, flexibility and confidence.
For further information, please contact Group Leader, Dr. Chunaram Choudhary, chuna.choudhary@cpr.ku.dk
Your application marked “211-0076/10-3850 – PhD stipend, proteomics, Choudhary” including a CV, publication list as well as names and contact details of 2 referees must be sent to the Novo Nordisk Foundation Center for Protein Research before 24 January 2011.
Your application should be sent by e-mail to jobs@cpr.ku.dk
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