Postdoctoral Research Position in Molecular B-Cell Immunology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York

A postdoctoral research position in Molecular B-Cell Immunology is available in the Herbert Irving Comprehensive Cancer Center (HICCC) at Columbia University, New York, NY. The laboratory's major research interests are focused on the elucidation of the molecular mechanisms that govern the differentiation of B cells within the germinal center (GC), the microenvironment that forms in the lymphoid tissues upon T-cell dependent activation of B cells to invading microorganisms. An equally important focus of the laboratory is to investigate whether and how the molecular mechanisms involved in normal GC B-cell differentiation are disrupted in B-cell tumors. Currently, a major line of investigation is the elucidation of the mechanisms controlling the exit of the GC reaction and the decision to become a memory B cell or a plasma cell. These questions will be addressed using a large spectrum of analysis methods, including transgenic mouse models.

Candidates should be highly motivated to perform basic research and have a strong interest in lymphocyte differentiation, and ideally have obtained prior knowledge on the phenotypic and molecular analysis of B cells. Candidates should have a PhD in biology or a related field and have experience in methods of molecular biology and flow cytometry. The position requires the ability to work independently and to have
excellent team working skills.

The HICCC (http://hiccc.columbia.edu) at the Columbia University Medical Campus (CUMC) provides a state-of-the- art research environment with access to technically sophisticated core facilities, including
genomics technologies, flow cytometry, proteomics, specialized microscopy, and transgenic mouse generation. The CUMC provides an excellent scientific and academic environment that fosters internal collaborations and attracts outside speakers that are leaders in their fields, thus providing cutting-edge knowledge of new developments in cancer genetics and immunology. The candidate will actively participate in the PhD-student/ Post-doc seminar series of the Department of Microbiology & Immunology to interact with fellow researchers and to discuss his/her data.

For consideration, please send a CV, a statement of research interests, and two names of references with contact information by e-mail to: Ulf Klein, Department of Pathology, and Microbiology & Immunology, Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St. Nicholas Avenue R312, New York, NY 10032, U.S.A.
E-mail: uk30@columbia. edu

Websites: http://www.microbiology.columbia.edu/faculty/klein.html,
http://156.111.235.11/pharm/cumc/profile.php?id=298


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