PhD Student, Sanquin Research, department of Plasma Proteins, location
Plesmanlaan Amsterdam (36 hours)
The research group:
The research program of the department of Plasma Proteins focuses on the characterization of the blood coagulation system and thrombus formation. Many proteins and cells regulate or influence the formation of a thrombus, thereby maintaining the haemostatic balance. Von Willebrand Factor and platelets play a key role in this process. Von Willebrand serves as adhesive surface for blood platelets at sites of vascular damage thereby preventing excessive bleeding.
Project:
Transfusion of platelets is the major contributant to treatment of patients suffering from excessive bleeding. Currently the efficacy of platelet transfusion is measured by the corrected count increment (CCI) of platelets at 1 hour and 24 hours after transfusion. Besides usage of the transfused platelets, clearance of platelets by macrophages is one of the major determinants of the CCI, and increased clearance of transfused platelets from the circulation can dramatically influence the outcome of patients. The aim of the project is to investigate which factors are involved in (increased) clearance of platelets from the circulation. The ultimate goal is to gain more insight into clearance of platelets from the circulation which is likely to contribute to improved quality of blood products in the future.
For the execution of this project several techniques will be used. Besides regular techniques such as (western) blotting, ELISA methods, molecular biological techniques, and fluorescent confocal microscopy, the PhD student will also perform real-time perfusion experiments and in-vivo experiments.
Requested:
* highly motivated candidate with affinity for scientific research;
* university degree in (medical) biology, biochemistry, biomedical sciences or medicine (or comparable).
Offered:
* challenging project within a young multidisciplinary research group;
* temporary position (4 years) as a PhD student;
* salary and conditions are conform CAO Sanquin.
Further information:
For further information please contact mr. dr. B. de Laat, tel.
020-5123120 or by e-mail b.delaat@sanquin. nl
Your written application, accompanied with a Curriculum Vitae, can be addressed to; Sanquin, unit HRM Plesmanlaan, attentions to mrs. D. de Vocht, Plesmanlaan 125, 1066 CX Amsterdam, or by email werk@sanquin. nl
o.i.o. job opening number TV 12-08.
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