Postdoc Biochemistry (1.0)
(Utrecht), 38 hours per week Utrecht University
Job description
Postdoc Biochemistry
Because pathogens become increasingly resistant to therapeutic drugs, and due to the emergence of new pathogens, novel approaches to the treatment of infectious diseases are required. By chemical cross-linking we have generated bifunctional proteins consisting of a lectin domain and a fragment of an antibody directed against Fc receptors on phagocytic cells. Studies in vitro in our laboratory have shown that such bifunctional proteins can stimulate uptake and killing of a broad spectrum of pathogens by recognizing the microbes through the lectin domain and targeting them to the phagocytes through the anti-Fc receptor part.
Your task will be to expand this work by:
1) varying the anti-Fc receptor moiety
2) developing a method for the production of the bifunctional proteins as fusion proteins
3) testing the effectiveness of the produced proteins with regard to their stimulation of pathogen uptake and killing by phagocytes in experiments in vitro. Depending on your affinity and experience, the effectiveness can also be studied in mouse infection experiments in vivo.
Requirements
Doctorate
We are looking for a biochemist, or medical molecular biologist, holding a PhD degree, who has experience with molecular biology, protein expression, various protein purification techniques and cell culture, and who has affinity with immunology. Candidates from the European Union are eligible for this position. Applications from the American continent will also be considered.
Organization
Utrecht University
Faculty of Veterinary Medicine
The Faculty of Veterinary Medicine www.vet.uu.nl is an internationally leading institute in veterinary scientific education, research and associated patient care. It ranks number one in Europe and among the top five institutes of veterinary science world-wide and is accredited by the American Medical Veterinary Association and the Canadian Medical Veterinary Association.
The Department of Biochemistry and Cell Biology invites applications for a
Postdoc Biochemistry
Conditions of employment
Estimated maximum salary per month: eur 3500 - 4000
Salaryscale 10.
Maximum salary amount in Euro's a month 3755
Employment basis: Temporary for specified period
Duration of the contract: 2 years
Maximum hours per week: 38
Additional conditions of employment:
We offer an experienced, collaborative and international group of colleagues and an excellent infrastructure that integrates molecular biology, biochemistry, life-cell imaging, and a state of the arts lipidomics facility. We take part in the Institute of Biomembranes www.biomembranes. nl the Academic Biomedical Centre www.abc.uu.nl and are engaged in many (inter)national collaborations.
We offer a fulltime temp. app. for 2 years.
Your gross salary will amount between EUR 2,861.- and EUR 3,755,- per month (full-time appointment in scale 10 of the Collective Labour Agreement of the Dutch Univ.), depending on previous qualifications and experience. Salaries are supplemented with a holiday bonus of 8% and a year-end bonus of 8,3% per year. There are outstanding secondary benefits, based on the CAO of NL Univ. and include e.g. a min. of 29 days holiday per year, an arrangement for study fac., generous contributions to healthcare, childcare, a pension scheme and flexible employment conditions.
Additional Information
Additional information about the vacancy can be obtained from:
Dr. J.J. Batenburg
Telephone number: +31 (0)30 253 5381
E-mail address: j.j.batenburg@ uu.nl
Or additional information can be obtained through one of the following links.
* About the organization
Application
You can apply for this job before 03-01-2009 by sending your application to:
The Faculty of Veterinary Medicine
Personnel department
M.E.J. Willemse-van Soest
Yalelaan 1
NL 3584 CL Utrecht
E-mail address: vacatures1@vet. uu.nl
Please send your application (including a cover letter, a CV, a statement of education, research interests and experimental methods used, and a detailed list of publications and achievements) , accompanied by the names and contact info of persons who are able to provide professional reference.
When applying for this job always mention the vacancy number 12896.
The short URL code for this job opening is: 00351-1787.
You can use this as a direct link to the job by adding the code to the URL www.academictransfe r.org/
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