This project is intended to create microscopic lasers to replace coded fluorescent beads in multiplexed bioassays. Current methods of coding are cumbersome and require labelled analytes to permit the analyte concentration to be determined. Our proposed laser method will provide a high degree of multiplexing, while also eliminating the need for labelling of analytes. The method will work either as a homogeneous assay using flow cytometric measurement methods, or as a heterogeneous assay where the microlasers are tethered to a surface. The homogeneous assay methodology would permit a high throughput of measurements, while the heterogeneous method would permit time courses to be measured or binding kinetics to be determined. The lasers will be created using two-photon stereolithography, using one of only three instruments of this type in the UK. This technique permits objects to be written with a resolution of ~ 150 nm.
see http://www.dtpstudentships.ls.manchester.ac.uk/howtoapply/ for details of the application process
Funding Notes:
Applicants must have obtained, or be about to obtain, a first or upper second class UK honours degree, or equivalent qualifications gained outside the UK, in an appropriate area of science or technology.
The studentship provides funding for fees and stipend at the Research Council UK rate and are available to eligible UK and EU nationals (due to funding criteria, EU nationals MUST have resided in the UK for three years prior to commencing the studentship). EU applicants that have not resided in the UK for three years prior to commencing the studentship, are eligible for a ‘fees only’
PhD Supervisor:Prof N Goddard
Application Deadline:25 November 2011
Please quote 10 Academic Resources Daily in your application to this opportunity!
