new gene signatures and drug targets. To this end, three approaches are developed: Identification of molecular targets, Preclinical and Clinical validation. Individual scientists and clinicians work together in groups mostly based on tumour type: sarcoma, breast cancer, colorectal cancer and lymphoma.
Scientific description: The aim of the research project is to investigate the role of ionic channels, intracellular calcium and pH in the regulation of the death receptors-mediated signaling pathways by using a wide range of technologies including patch-clamp electrophysiology, calcium imaging, molecular and cellular physiology and biochemical techniques.Biologic al materials used in this study will include lymphocytes issued from blood samples of healthy donors and patients with lymphocyte malignancies, and cell lines.
Position: 24 months postdoctoral fellowship(starting January, 2011) funded by the National Cancer Institute (INCa).The wages will be around 2000 euros/month.This position is seeking candidates interested in pursuing an academic research career.
Profile: Ideal candidates must have a recent Ph.D. degreeand/or M.D. with substantial research experiencein biochemistry, electrophysiology, molecular, cellular or cancer biology, or a related discipline. Previous work in the field of cancer biology is preferred. A good expertise in the area of apoptosis/cell deathor immunology will be appreciated.
Successful candidate will leadan innovative and integrated project at the interface of electrophysiology and biology.Opportuniti es to be part of several ongoing collaborations will enhance the opportunity for publications.
Location: University of Bordeaux, Bergonié Cancer Institute, Bordeaux, France. Bordeaux, capital of Aquitania, combines high-level research laboratories and a unique quality of life in a renowned cultural setting.
Requirements:
- Technical independence with cell culturing, transfections, Western blotting, patch clamp electrophysiology, calcium imaging, and standard molecular and cell biology techniques.
- Meticulous at planning, executing, and organizing experiments
- Candidate must also be able to take initiative, to work independently and in a collaborative setting
- A good publication record in recognized peer-reviewed journals
Application:
Candidates should send a cover letter summarizing qualifications and experience, updated curriculum vitae includingpublicatio nslistand three academic reference letters with names/addresses/ e-mail contacts to: Dr. Pierre VACHER (e-mail: Pierre.Vacher@ inserm.fr).
INSERM U916, Institut Bergonié, 229 cours de l'Argonne 33076 Bordeaux Cedex, France
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