The interdependence of bacterial metabolism and cell-cell communication signal molecule generation
A studentship is available within the expanding metabolomic group at the University of Nottingham to study the interplay between metabolism and bacterial cell-cell communication (also known as quorum sensing). Quorum sensing is employed by numerous bacteria to co-ordinately regulate gene expression in response to their cell density using small diffusible signal molecules, and contributes to the virulence of important pathogens such as Pseudomonas aeruginosa. Ps. aeruginosa is an opportunistic pathogen which causes persistent, often fatal infections in the immunocompromised and especially cystic fibrosis sufferers. It has a complex hierarchy of quorum sensing circuits producing signalling molecules which include N-acyl homoserine lactones and 2-alkyl-4(1H)-quinolones. The biosynthesis of these molecules draws on metabolic pathways including those involved in amino acid and fatty acid generation.
The project will involve the application of existing methodologies available in Nottingham to assess the consequences of signal molecule synthesis on metabolism and virulence as well as the impact of metabolic perturbances upon signal molecule generation. In addition, novel analytical methodology will also be developed and optimised. Thus, this project will be suitable for individuals with strong analytical chemistry backgrounds who have an interest in microbiology and genetic engineering. The metabolomic group spans the Schools of Pharmacy and Molecular Medical Sciences, and is integral to research teams within the Institute of Infection, Inflammation and Immunity.
The eligibility criteria for this studentship is available at: http://www.bbsrc.ac.uk/funding/training/eligibility.pdf.
Informal enquiries may be addressed to Dr D Barrett, Email: David.Barrett@Nottingham.ac.uk or Dr K Hardie, Email: Kim.Hardie@Nottingham.ac.uk.
Applications, with a detailed CV and the names and addresses of two referees, should be sent to Mrs D Mitchell, Centre for Biomolecular Sciences, School of Molecular Medical Sciences, The University of Nottingham, University Park, Nottingham, NG7 2RD. Email: Diane.Mitchell@Nottingham.ac.uk.
Reference : MED133
Closing Date : Open until filled
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