Oct 24, 2010

PhD position: Functional aspects of MHC class II molecules on T-cells, Aalborg University, Denmark

Position No.

At the Faculty of Engineering and Science, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University in collaboration with the Department of Clinical Immunology and Regional Transfusion Centre, Aalborg Hospital, a PhD Stipend is open for appointment as from December 1, 2010.

The position is available within the general study programme Biotechnology, Chemistry and Environmental Engineering.

Job description
Functional aspects of MHC class II molecules on T-cells

For several decades it has been observed both in vitro and in vivo that proteins considered as being cell-specific were found on the surface of other cell types. In this context, it has been demonstrated that T-cells can acquire MHC class II molecules from other immune cells. The significance of this acquisition has been proposed to relate to immune amplification, regulation, and tolerance. However, the exact molecular and cellular mechanisms as well as the functional consequences of this intercellular protein transfer have yet to be delineated.
This project is aimed at elucidating the functional aspects of the in vitro intercellular trans-fer of MHC class II molecules from human antigen presenting cells to T-cells in different inflammatory milieus. The cellular and molecular mechanisms pertaining to the acquisition will also be investigated. The study will employ and combine methodologies and technologies of immunology and mass spectrometry driven proteomics.

The Ph.D. project will be supervised by Associate Professor Allan Stensballe (Aalborg University), Cand. Polyt. Malene Jørgensen (Aalborg Hospital), and Cand. Med. Kim Varming (Aalborg Hospital).

You may obtain further information concerning the technical aspects of the stipend from Associate Professor Allan Stensballe, Department of Biotechnology, Aalborg University (phone: (+45) 9940 9128, email: as@bio.aau.dk ) or Cand. Polyt. Malene Jørgensen, Department of Clinical Immunology, Aalborg Hospital (phone: (+45) 9932 1157, email: maljoe@rn.dk ).

PhD stipends are allocated to individuals who hold a Masters degree. PhD stipends are normally for a period of 3 years. It is a prerequisite for allocation of the stipend that the candidate will be enrolled as a PhD student at the Doctoral School of the Faculty of Engineering and Science, in accordance with the regulations of Ministerial Order No. 18 of January 14, 2008 on the PhD Programme at the Universities. According to the Ministerial Order, the progress of the PhD student shall be assessed every six months. It is a prerequisite for continuation of salary payment that the previous progress is approved at the time of the evaluation.

The qualifications of the applicant will be assessed by an assessment committee. On the basis of the recommendation of the assessment committee, the Dean of the Faculty of Engineering and Science will make a decision for allocating the stipend.

For further information about stipends and salary contact Ms. Maj-Britt Trolle Ståhl, The Faculty of Engineering and Science, email: mts@adm.aau.dk, phone: +45 9940 7582.

The faculty have a research school, The Doctoral School of Engineering, Science and Medicine: www.phd.ins.aau.dk and a Network for all PhD students: www.pau.aau.dk

Appointment and salary as a PhD fellow are according to the Ministry of Finance Circular of October 1, 2008 on the Collective Agreement for Academics in Denmark, Appendix 5, regarding PhD fellows, and with the Ministry of Finance Circular of June 13, 2007 on the employment structure at Danish Universities.



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