Applications are invited from students with a suitable qualification in pharmacology or biochemistry (or a related discipline) for a four-year BBSRC-funded studentship entitled “Regulation of vascular tone by intracellular signal transduction pathways”. The level of tone in a blood vessel is determined by the balance between the contractile signals and the vasodilator signals received by the vascular smooth muscle. Traditionally, vasoconstriction has been perceived to be caused by an increase in intracellular calcium leading to activation of myosin light chain kinase and phosphorylation of the regulatory myosin light chains. However, more recently it has been demonstrated that smooth muscle contraction can be regulated by other signal transduction mechanisms such as Rho kinase, ERK-MAP kinase and protein kinase C. This project will investigate the role of ERK-MAP kinase in the regulation of vascular tone. A combination of pharmacological and biochemical techniques will be used to measure vascular tone and changes in intracellular signal transduction pathways.
This project will be jointly supervised by Dr Richard Roberts and Dr Steve Alexander. Further information is available at: http://www.nottingham.ac.uk/biomedsci/.
The successful student will be registered for a PhD (MPhil in the first instance).
This studentship is available for a period of four years and provides a postgraduate stipend of £12,600 per annum.
Informal enquiries may be addressed to Dr Roberts, Email: Richard.Roberts@Nottingham.ac.uk.
Applications, with a detailed CV and the names and addresses of three referees, should be sent to Dr R Roberts, School of Biomedical Sciences, Queen’s Medical Centre, Nottingham, NG7 2UH.
Reference : MED124
Closing Date : Monday 26 March 2007
http://jobs.nottingham.ac.uk/vacancies.aspx?cat=345#j1369
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