Biophysical, cell biological and structural analysis of the protein interaction networks controlling intracellular vesicular transport (Institute for Molecular Bioscience, University of Queensland, Australia)
PhD position in Molecular, Chemical and Structural biology is available in the group of Dr. Kirill Alexandrov. Our group is relocating from the Max-Planck-Institute for Molecular Physiology in Dortmund, Germany to the Institute for Molecular Bioscience (IMB) in Brisbane Australia in summer 2008. We are working in the broad area of eukaryotic biology with a focus on the intracellular vesicular transport and the role of prenylated proteins in this process. We are actively developing new technologies for protein research and production and apply them for understanding mechanics and thermodynamics of protein:protein and protein:ligand interactions.
The IMB was established several years ago to spearhead interdisciplinary research in organismal, cellular, chemical and structural biology. It is located in the newly built complex on the campus of The University of Queensland in Brisbane. The group will be linked to the research activities of the neighboring Australian Institute for Bioengineering and Nanotechnology which is focused on the developing cutting edge biotechnological processes. Both institutes are exceptionally well equipped and funded and provide the vibrant research environment with more then 50 research groups.
We are seeking a PhD candidate with the background in chemistry, biochemistry, cellular, molecular or structural biology. The position provides an outstanding training program in protein biochemistry, chemical, structural and molecular biology, in a generously funded, dynamic, and team-oriented research program.
Please apply by sending your CV and e-mail and telephone numbers of 3 references to: E-mail applications will be preferred
PLEASE PUT: “Application for Ph.D at the IMB ” into the subject line
kirill.alexandrov@mpi-dortmund.mpg.de
Dr. Kirill Alexandrov
Labartory of molecular mechanisms of vesicular transport
Department of Physical Biochemistry
Max-Planck-Institute for Molecular Physiology
Otto-Hahn-Strasse 11
44227 Dortmund
Germany
http://www.mpi-dortmund.mpg.de/forschungProjekte/AGs/AGAbtIII/Alexandrov/index.html
http://www.uq.edu.au/
http://www.aibn.uq.edu.au/
Phone +49-231-1332356
Fax +49-231-1331651
Funding Notes
approx. AUS$2000/months + health insurance
Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody RS, Alexandrov K. Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell. 2004 Jun 11;117(6):749-60.
Kushnir S, Gase K, Breitling R, Alexandrov K. Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae. Protein Expr Purif. 2005 ;42(1):37-46.
Dursina B, Reents R, Delon C, Wu Y, Kulharia M, Thutewohl M, Veligodsky A, Kalinin A, Evstifeev V, Ciobanu D, Szedlacsek SE, Waldmann H, Goody RS, Alexandrov K. Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc. 2006 128(9):2822-35.
Kushnir S, Marsac Y, Breitling R, Granovsky I, Brok-Volchanskaya V, Goody RS, Becker CF, Alexandrov K. Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation. Bioconjug Chem. 2006; 17(3):610-16
Pylypenko O, Rak A, Durek T, Kushnir S, Dursina BE, Thomae NH, Constantinescu AT, Brunsveld L, Watzke A, Waldmann H, Goody RS, Alexandrov K. Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J. 2006 Jan 11;25(1):13-23.
Wu Y., Tan K-T, Waldmann H., Goody R.S. and Alexandrov K., Quantitative analysis of the interaction of prenylated Rab proteins with REP and GDI explains the requirement for both regulators in Rab function. PNAS 2007 Jul 24;104(30):12294-9.
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