Faculte de Medicine, INSERM
A potential role of the peroxisome proliferator-activated receptor beta (PPAR beta) in cardiac growth and vascularization – testing the therapeutic potential
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamiliy. Agonists for PPAR alpha (fibrates) and PPAR gamma (thiazolidinediones) are in clinical use as lipid lowering drugs and insulin sensitizers and have in addition some beneficial cardiovascular effects. More recently, PPAR beta agonists were suggested as being of potential therapeutic use for metabolic syndrome. We detected that short-term treatment of mice with a specific PPAR beta agonist stimulates cardiac myocyte growth and vascular proliferation.
The aim of the present study is the characterization of the time course of the stimulatory effects of PPAR beta agonists on cardiac growth and vasculogenesis, the identification of potential underlying molecular mechanisms, and finally, the determination of a potential therapeutic use of PPAR beta activators for the treatment of cardiac dysfunction induced by experimental myocardial infarction in mice.
Funding Notes
A master 2 or equivalent degree is required. Possible starting date until October 2008.
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The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction.FASEB J. 2002 Jul;16(9):1117-9.
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