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The Austrian Centre of Biotechnology (ACIB, www.acib.at) in Vienna has a long term programme on optimization of Chinese Hamster Ovary cells and their use in biotechnological production of therapeutic proteins.
In the current project the genetic information of the Chinese Hamster that is available to BOKU should be further analysed specifically with regards to identification of endogenous promoters of CHO cells, primarily those that are highly expressed and / or regulated. Within the project, the sequence data will be analysed for coding sequences, and upstream promoter regions identified. In addition tools for studying promoter stability and silencing should be developed. ACIB is seeking PhD candidate in the field of bioinformatics.
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