PhD Studentship: EPSRC Molecular Nose Project
Modelling and analysis of sensed behaviours in biochemical networks
Supervisor: Professor Muffy Calder
The Molecular Nose is an exciting, large interdisciplinary research project involving biochemistry, cell biology, engineering, chemistry, and computing science. The goal of the project is to build a multiplexed sensor platform that can assess and quantify dynamic changes in the functional state of biochemical networks in mammalian cells, and use these data to reconstruct cell network interactions and their dynamic behaviour on a systems wide level. The concept underpinning this platform is fundamentally different from existing methods used in the biological sciences to assess cell function, and similar to the Electronic Nose, where an array of sensors is trained with individual stimuli to establish a library of response patterns which subsequently are used to deconvolute complex inputs. In this project, Professors Calder and Girolami (Computing Science) will establish a computational framework of modules for the interpretation of input-output relationships and prediction of functional network behaviours in response to perturbations. The aim of this studentship is to analyse and predict how modules interact with each other. The
starting point will be Calders previous work on the interaction of features in telecommunications networks, and also process algebraic models of biochemical networks.
The studentship is for four years.
The studentship is suitable for candidates with a good first degree (or Masters) in Computing Science or Mathematics, a willingness to engage with biochemistry and engineering and to work as part of a interdisciplinary team.
The closing date is 30 June 2007.
The application procedure can be found at
http://www.dcs. gla.ac.uk/ phd/application. html.
Informal enquiries to: muffy@dcs.gla. ac.uk.
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