Several 3-year post-doctoral fellowships are available in the laboratory of Dr John Diffley at Cancer Research UKs London Research Institute, based in the Clare Hall Laboratories.
We are interested in understanding the mechanism and regulation of DNA replication. We study the process in budding yeast, mouse and human cells. We are interested in several questions:
- What are the mechanisms involved in initiating DNA replication?
- How is DNA replication regulated during the cell cycle?
- How is DNA replication regulated in response to DNA damage?
- Does the misregulation of DNA replication contribute to cancer genesis?
Candidates should have a strong background in either: biochemistry, yeast, genetics, mammalian cell culture or mouse models.
Publications:
- Segurado and Diffley (2008) Genes & Development 22:1816-1827
- Baxter and Diffley (2008) Molecular Cell 30:790-802
- Zegerman and Diffley (2007) Nature 445:281-285
- Mailand and Diffley (2005) Cell 122:915-926
Salary in the range of GBP 25,500 33,000, plus location allowance of GBP 2470, plus benefits.
Please submit a full cv and covering letter to john.diffleycancer.org.uk by 15th August 2008
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