A Marie Curie Early-Stage Researcher’s position is available in Marseille, France, for 3 years in frame of a RTN-project Translocation that focuses on the role of membrane permeability on the bacterial antibiotic suceptibility. One Young and motivated Researcher that wish to enrol in Ph.D. programme in the frame of this RTN project - implying the delivery at the end of its fellowhip of a co-directed thesis - will be offered a three-year fellowship including a salary, the conditions to be trained on collaborative research, academics, research, dissemination activities, and will be asked totake part actively to the work and life of this Research network.
Membrane of gram negative bacteria, enterobacteriaceae, is a major barrier for the penetration of various molecules. In this context, the study of membrane permeability is a key point to elucidate the susceptibility/resistance aspects governing the activity of ß-lactams, fluoroquinolones, etc, major classes of antibiotics currently used in human therapy. We are looking for a doctoral fellow that will be interested in research focused on the study on outer membrane proteins of Enterobacteriaceae and on multi-drug-resistance in Enterobacteriaceae, (genetic and regulation, structure-function, and biochemical approaches).
Some molecular biology or microbiology ability/experiences (pre-doc experiments in bacterial culture or plasmid manipulations, …..) are necessary to integrate the team working on bacterial membrane strategy. The project will be centered on the characterization (genetic and functional expression) of membrane channels which condition antibiotic susceptibility in collaboration with other Translocation-teams.
The EA2197 is located on the Medecine Campus –La Timone-. It is composed of interacting groups working on various aspects of bacterial membrane proteins (genetic, biochemistry, ..) and membranotropic compounds (synthesis, structure, ..).
The Research Training Network Translocation (FP6 - Marie Curie Research training network ‘MRTN-CT-2005-019335 Translocation’) will start early in 2006 and will last four years. Our interdisciplinary project focuses on understanding the molecular basis of antibiotic permeation across the outer membrane of Gram-negative bacteria and involves characterization of transport at the molecular level, non-equilibrium molecular modeling, physical chemistry of transport, microbiology of antibiotic resistance, antibiotic drug design and development of high throughput screening systems involving electrophysiology, fluorescence and microfluidics. The candidates will be based at one of the partner laboratories and should have interests that will enable them to collaborate effectively with several of the other laboratories.
The partner laboratories are: biophysics at the International University Bremen (M.Winterhalter, m.winterhalter@iu-bremen.de), molecular modelling at the University of Cagliari (M.Cecarelli, matteo.ceccarelli@dsf.unica.it), physical chemisrty at the University of Porto (P. Gameiro, agsantos@fc.up.pt), microbiology at the Universite de Mediteranee (J.-M. Pages, jean-marie.pages@medecine.univ-mrs.fr), biophysics at the Ecole Polytechnique de Lausanne (H. Vogel, h.vogel@epfl.ch), engineering at Nanion in München (N. Fertig, niels@nanion.de) and antibiotic design and discovery at Basilea in Basel (M.G.P. Page, malcolm.page@basilea.com). Further information on the activities of the individual groups can be obtained from the respective group leaders.
Organisation - Université de la Méditerranée
Division/Faculty/Department - Medecine - Bacterial wall, Permeability and Antibiotics - EA 2197
Street - 27, Bd Jean Moulin
City - Marseille
Postal Code - 13385
Country - FRANCE
E-Mail - Jean-Marie.PAGES@medecine.univ-mrs.fr
http://www.univmed.fr/recherche/lab.asp?lng=GB&view=unit&id=71
http://www.univmed.fr/europe/default.aspx?id=56480
Application Deadline - 30/09/2006
