Dec 10, 2009

Post-Doc Position (TVL-E13) in Molecular Immunology/Signal Transduct

Project description: On March 13th, 2006 the anti-human CD28 superagonistic antibody TGN1412 was applied to six healthy volunteers in the course of a phase I clinical study. Completely unexpectedly, the antibody caused a massive and live threatening cytokine storm in all six volunteers whose molecular basis is still not completely understood. The project aims at elucidating the signalling properties of anti-human CD28 superagonistic antibodies by applying cell biology, molecular and biochemical techniques.

Waibler et al., PLoS ONE (2008) 3(3):e1708;
Schraven & Kalinke, Immunity (2008) 28(5):591-5

The project is part (TP15) of the newly installed collaborative research center 854 (SFB 854, Speaker Prof. Schraven). The project is headed by Prof. Burkhart Schraven and will be conducted in close collaboration with the group of Prof. Ulrich Kalinke at the TWINCORE Centre for Translational Medicine in Hannover and the Helmholtz-Centre for Infectious Research (HZI) in Braunschweig.

The Institute of Molecular and Clinical Immunology at the Medical Faculty of the Otto-von-Guericke- University of Magdeburg provides top-level research conditions and state of the art facilities.

Applicants are expected to possess a PhD or MD (or equivalent) in Natural or Life Sciences, (Medicine, Biochemistry, Biology). Further we expect a high motivation, creativity and a strong interest to shape your own research project. An integrative and cooperative personality and very good communication skills in German and/or English are highly appreciated.

Previous experience in biochemistry, molecular biology and microscopy is a plus. Appreciated is also experience in fluorescence microscopy / live cell imaging, flow cytometry or other aspects of cellular immunology. Willingness for animal experimentation with mice is an indispensable prerequisite for the position. The position can be filled immediately.

For further information please contact Prof. Schraven under 0049-391-67- 15800 or by E-Mail:

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