Project: "Metabolic Modulation of Growth Factors".
The aim for the thesis is to investigate mechanisms of transcription and gene expression regulation in growth factor IGF-1 and IGF-2 genes, IGFBP-s (IGF binding proteins) and IGF Receptor genes. Results of study can be of importance in animal production as they potentially allow increase protein content and decrease fat content. Hypothesis is based on feed dependant IGF-1 gene expression modulation case. Type and level of IGF regulation has to be studied. The cytokine insulin-like growth factor-1 (IGF-1) is considered to mediate anabolic growth hormone actions. In addition, locally expressed IGF-1 is an important growth regulator acting in an auto- and paracrine manner. Cattle serum IGF-1 level in puberty shows correlation with protein and fat production in animal first lactation. Long-term treatment with n3-PUFAs can result in decrease of IGF-1 mRNA content in muscle cells and in depressed protein synthesis in animal body.
Requirements: The ideal candidate must hold a Master's degree (or equivalent) in biochemistry, molecular biology or animal sciences, have good communication skills, be able to work in a team and be highly motivated to conduct fundamental scientific research.
The doctoral fellowship is based on a scholarship. The assignment period is normally four years. The candidate will work part time as research/teaching assistant with a workload not exceeding one year during the four year assignment period. Applicants should have a background and a language proficiency (preferably Estonian, but English is also acceptable) to be able to work as assistant in regular courses given by the Department.
Applicants must qualify for admission to the PhD program at the EMU. See http://www.emu.ee/141969
Application: For further questions and to apply, contact:
Estonian University of Life Sciences
Institute of Veterinary Medicine and Animal Sciences
attn: Avo Karus (avo.karusemu.ee)
Kreutzwaldi 1
Tartu, 51014 ESTONIA
http://www.emu.ee/141969
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