PhD student on bone-inducing biomaterials
University of Twente Faculty of Science and Technology
Job description
PhD-project on bone tissue engineering: Engineering and investigating osteo-inductive materials
Calcium phosphate ceramics are widely applied as bone fillers because bone cells migrate along the surface into the bone defect. In addition, ceramics have been developed which induce bone formation upon implantation in, for instance, muscle tissue. These ceramics exhibit superior bone filling properties in large bone defects in animals and are currently tested in a clinical trial. Unfortunately,
the molecular mechanism underlying osteo-inductivity is unknown and also porosity is currently the only design criterion influencing osteo-inductivity, which hampers further development of osteo-inductive materials.
In this project, we aim to approach osteo-inductivity from two radically different angles. First, we will try to design osteo-inductive scaffolds by generating ceramics with a predefined geometry using lithographic technology. Osteo-inductivity will be tested in appropriate animal models. Secondly, we will try to unveil the biology behind osteo-inductivity by following recently discovered leads towards the behaviour of mesenchymal and embryonic stem cells on inductive and non-inductive materials in vitro and in.
Required education/skills:
We offer a temporary position for 4 years with a competitive salary in a top level research and academic environment with excellent opportunities for personal development. The work is highly interdisciplinary and the atmosphere in the group as well as at the institute is collegial and collaborative. Candidates will contribute
to the bachelor and master courses Biomedical Engineering and Technical Medicine. We are looking for an enthusiastic PhD student who can bridge the fields of biomaterial sciences and cell biology. Your starting salary will be € 1956, - in the first year and up to € 2502, - gross per month in the last year.
Conditions of employment:
Estimated maximum salary per month: eur 2000 - 2500
Salary: scale 10.
Maximum salary amount in Euro's a month 2502
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 38
Additional information about the vacancy can be obtained from:
Dr. Jan de Boer
Telephone number: 3130 2295154
E-mail address: j.deboer@tnw. utwente.nl
Or Dr Marcel Karperien
E-mail address: h.b.j.karperien@ tnw.utwente. nl
Or additional information can be obtained through one of the following links:
* About the organization (http://www.utwente. nl/en/)
* About the function
(http://www.utwente. nl/vacatures/ vacatures_ externe_werving/ 07-116-117- 118-119-eng. doc/)
* website tissue regeneration (http://tr.tnw. utwente.nl)
Application
You can apply for this job before 02-09-2007 (dd-mm-yyyy) by sending
your application to:
University of Twente
faculty TNW
drs.M.D. Hilderink
Postbus 217
7500 AE Enschede
E-mail: PenO@tnw.utwente. nl
When applying for this job always mention the vacancy number AT/07/117.
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