Denmark. Department of Micro- and Nanotechnology are offering 1 PhD scholarship in the LiMeS project:
In humans the number of metabolites amounts to about 2500 and can be assumed to be about the same in plants. Since metabolites are involved in all cellular processes, the knowledge of their concentration profiles in time and space is a key to understand cellular processes. Although the majority of metabolic pathways and transport processes are known, the over-all balance of metabolites in a cell in different states and the influence of this balance on cellular functions are poorly understood. The challenge ahead is to develop novel tools, which allow measurement of metabolite fluctuations in living cells, relate them to physiological changes and model the metabolic pathways involved.
Many animal and human diseases are caused by malfunction of metabolic or signal pathways. An example is neurodegenerative diseases such as Parkinson's, which apparently involve the improper function of glutamate, the predominant excitatory neurotransmitter. Another example is that a precise knowledge of pH in the endocytotic pathway in cancer cells will provide an opportunity for developing drug
delivery systems for cancer treatment. Furthermore Reactive Oxygen Species, ROS, are involved in a variety of diseases and represent a third example where the development of anti-oxidant therapeutics could benefit from in vivo monitoring of ROS. Finally, targeted fertilization of crop plants is a biotechnological prerequisite for a modern, efficient and sustainable agriculture.
The project LiMeS (Time-resolved metabolite quantifications in living cells using optical nanosensors) is a interdisciplinary collaboration between researchers at the Danish Universities: Technical University of Denmark (DTU), University of Copenhagen (KU), and University of Southern Denmark (SDU). LiMeS seek to combine competences to construct a versatile technology platform with the vision of achieving nanosensors, which is applicable to any analyte in cells of any organism.
At DTU, Department of Micro- and Nanotechnology we are offering 1 PhD scholarship in the LiMeS project:
A Ph.D. Scholarship in design and synthesis of nanoparticle based sensor systems. Nanoparticles will be synthesized by free radical polymerization. Size control is achieved through the use of microemulsions as reactors. Motivated by knowledge from the drug delivery field on how to obtain particle uptake in cells, particles
surface functionalized with ligands that recognize surface-expressed receptors in cells is a synthetic target. For more information contact Kristoffer Almdal (kristoffer.almdal@ risoe.dk) +45 4677 4785 or Senior Scientist Thomas Andresen (thomas.andresen@ risoe.dk) +45 4677 5480 or visit (www.dtu.dk/ vacancy).
LiMeS (http://www.cbio. dk/LiMeS. html) is sponsored by The Danish Research Council for Technology and Production Sciences through grant 274-07-0172
Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering.
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. Information about the general requirements for enrolment and the general planning of the scholarship studies is included in the general rules of DTU, which may be obtained by application to the PhD programme office at tel: +45 45 25 11 76 or +45
45 25 11 77.
The salary and appointment terms are consistent with the current rules for PhD degree students.
Application
We need your online application no later than September 1st, 2008 at 12.00 noon. Open the link “apply online� fill out the form and attach application, a curriculum vitae and documentation of a completed master’s degree.
All interested candidates irrespective of age, gender, race, religion or ethnic background are encouraged to apply.
http://www.dtu. dk/English/ About_DTU/ vacancies. aspx?guid= 22663996
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